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Poly-L-lactic acid (PLLA) is a widely used biomaterial
known for its biocompatibility and biodegradability.

This reference is provided as general scientific background on PLLA and does not constitute product-specific clinical evidence for Olidia.

Scientific Background Reference
Farahani A, Zarei-Hanzaki A, Abedi HR, Tayebi L, Mostafavi E. Polylactic acid piezo-biopolymers: chemistry, structural evolution, fabrication methods, and tissue
engineering applications. J Funct Biomater. 2021;12:71.

Polymeric Structure Molecular Micro-Tuning - PSMMT
PLLA and
Skin Regeneration
Olidia sets a new standard in skin regeneration
with its optimal combination of ingredients.
Learn More
Recent advances in collagen biostimulators for facial rejuvenation: A systematic review in aesthetic dermatology.
Polylactic acid (PLA): Properties, synthesis, and biomedical applications – A review of the literature.
Physicochemical Characteristics and Hydrolytic Degradation of Polylactic Acid Dermal Fillers: A Comparative Study
In Vivo Evaluation of the Anti-Skin-Ageing Bioactivity of a Recombinant Dual Humanised Collagen and Ploy-L-Lactic Acid
Poly-L-Lactic Acid Fillers Improved Dermal Collagen Synthesis by Modulating M2 Macrophage Polarization in Aged Animal Skin
Olidia is a scientific solution
that goes beyond simple aesthetics.
We restore innate beauty through skin science
based on regenerative medicine.
Drawing from clinical insights and research,
we have developed safe and effective dermal fillers,
continuously redefining beauty through science.
PRP Science Co., Ltd.
Olidia Developer
DR. Moon Seok Shin, Dermatology
Optimal formulation
for skin regeneration activation
  • PLLA
  • CMC
    Moreover, in parenteral suspension injection, thixotropic fluid (CMC) plays an essential role in making the injection feel comfortable and accessible through the skin.
    : Rahman MS, Hasan MS, Nitai AS, Nam S, Karmakar AK, Ahsan MS, Shiddiky MJA, Ahmed MB. Recent developments of carboxymethyl cellulose. Polymers. 2021;13:1345. p.7. doi:10.3390/polym13081345. (CC BY 4.0)
    URL: https://www.mdpi.com/2073-4360/13/8/1345
  • Mannitol
    In addition, the chemical characteristics of mannitol make it as an antioxidant of choice in combination with HA, particularly because of its hydro-solubility compared with other antioxidants such as vitamin E which is lipid soluble, or 𝛽-caroten which is insoluble in water.
    : Rinaudo M, Lardy B, Grange L, Conrozier T. Effect of mannitol on hyaluronic acid stability in two in vitro models of oxidative stress. Polymers. 2014;6:1948-1957. p.8. doi:10.3390/polym6071948. (CC BY 4.0)
    URL: https://www.mdpi.com/2073-4360/6/7/1948
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